SplicePort--An interactive splice-site analysis tool

TitleSplicePort--An interactive splice-site analysis tool
Publication TypeJournal Articles
Year of Publication2007
AuthorsDogan RI, Getoor L, Wilbur WJ, Mount SM
JournalNucleic Acids Research
IssueWeb Server
PaginationW285-W291 - W285-W291
Date Published2007/05/08/
ISBN Number0305-1048, 1362-4962

SplicePort is a web-based tool for splice-site analysis that allows the user to make splice-site predictions for submitted sequences. In addition, the user can also browse the rich catalog of features that underlies these predictions, and which we have found capable of providing high classification accuracy on human splice sites. Feature selection is optimized for human splice sites, but the selected features are likely to be predictive for other mammals as well. With our interactive feature browsing and visualization tool, the user can view and explore subsets of features used in splice-site prediction (either the features that account for the classification of a specific input sequence or the complete collection of features). Selected feature sets can be searched, ranked or displayed easily. The user can group features into clusters and frequency plot WebLogos can be generated for each cluster. The user can browse the identified clusters and their contributing elements, looking for new interesting signals, or can validate previously observed signals. The SplicePort web server can be accessed at http://www.cs.umd.edu/projects/SplicePort and http://www.spliceport.org.