Sequencing and Genome Assembly Using Next-Generation Technologies

TitleSequencing and Genome Assembly Using Next-Generation Technologies
Publication TypeBook Chapters
Year of Publication2010
AuthorsNagarajan N, Pop M
EditorFenyö D
Book TitleComputational BiologyComputational Biology
Series TitleMethods in Molecular Biology
Pagination1 - 17
PublisherHumana Press
ISBN Number978-1-60761-842-3

Several sequencing technologies have been introduced in recent years that dramatically outperform the traditional Sanger technology in terms of throughput and cost. The data generated by these technologies are characterized by generally shorter read lengths (as low as 35 bp) and different error characteristics than Sanger data. Existing software tools for assembly and analysis of sequencing data are, therefore, ill-suited to handle the new types of data generated. This paper surveys the recent software packages aimed specifically at analyzing new generation sequencing data.