%0 Journal Article %J Journal of BacteriologyJ. Bacteriol. %D 2010 %T Genome Sequence of Hybrid Vibrio Cholerae O1 MJ-1236, B-33, and CIRS101 and Comparative Genomics with V. Cholerae %A Grim,Christopher J. %A Hasan,Nur A. %A Taviani,Elisa %A Haley,Bradd %A Jongsik Chun %A Brettin,Thomas S. %A Bruce,David C. %A Detter,J. Chris %A Han,Cliff S. %A Chertkov,Olga %A Challacombe,Jean %A Huq,Anwar %A Nair,G. Balakrish %A Rita R Colwell %X The genomes of Vibrio cholerae O1 Matlab variant MJ-1236, Mozambique O1 El Tor variant B33, and altered O1 El Tor CIRS101 were sequenced. All three strains were found to belong to the phylocore group 1 clade of V. cholerae, which includes the 7th-pandemic O1 El Tor and serogroup O139 isolates, despite displaying certain characteristics of the classical biotype. All three strains were found to harbor a hybrid variant of CTXΦ and an integrative conjugative element (ICE), leading to their establishment as successful clinical clones and the displacement of prototypical O1 El Tor. The absence of strain- and group-specific genomic islands, some of which appear to be prophages and phage-like elements, seems to be the most likely factor in the recent establishment of dominance of V. cholerae CIRS101 over the other two hybrid strains. %B Journal of BacteriologyJ. Bacteriol. %V 192 %P 3524 - 3533 %8 2010/07/01/ %@ 0021-9193, 1098-5530 %G eng %U http://jb.asm.org/content/192/13/3524 %N 13 %R 10.1128/JB.00040-10