TY - JOUR T1 - Genome Sequence of Hybrid Vibrio Cholerae O1 MJ-1236, B-33, and CIRS101 and Comparative Genomics with V. Cholerae JF - Journal of BacteriologyJ. Bacteriol. Y1 - 2010 A1 - Grim,Christopher J. A1 - Hasan,Nur A. A1 - Taviani,Elisa A1 - Haley,Bradd A1 - Jongsik Chun A1 - Brettin,Thomas S. A1 - Bruce,David C. A1 - Detter,J. Chris A1 - Han,Cliff S. A1 - Chertkov,Olga A1 - Challacombe,Jean A1 - Huq,Anwar A1 - Nair,G. Balakrish A1 - Rita R Colwell AB - The genomes of Vibrio cholerae O1 Matlab variant MJ-1236, Mozambique O1 El Tor variant B33, and altered O1 El Tor CIRS101 were sequenced. All three strains were found to belong to the phylocore group 1 clade of V. cholerae, which includes the 7th-pandemic O1 El Tor and serogroup O139 isolates, despite displaying certain characteristics of the classical biotype. All three strains were found to harbor a hybrid variant of CTXΦ and an integrative conjugative element (ICE), leading to their establishment as successful clinical clones and the displacement of prototypical O1 El Tor. The absence of strain- and group-specific genomic islands, some of which appear to be prophages and phage-like elements, seems to be the most likely factor in the recent establishment of dominance of V. cholerae CIRS101 over the other two hybrid strains. VL - 192 SN - 0021-9193, 1098-5530 UR - http://jb.asm.org/content/192/13/3524 CP - 13 M3 - 10.1128/JB.00040-10 ER -