@article {14099,
	title = {Schistosoma mansoni genome: Closing in on a final gene set},
	journal = {Experimental Parasitology},
	volume = {117},
	year = {2007},
	month = {2007/11//},
	pages = {225 - 228},
	abstract = {The Schistosoma mansoni genome sequencing consortium has recently released the latest versions of the genome assembly as well as an automated preliminary gene structure annotation. The combined datasets constitute a vast resource for researchers to exploit in a variety of post-genomic studies with an emphasis of transcriptomic and proteomic tools. Here we present an innovative method used for combining diverse sources of evidence including ab initio gene predictions, protein and transcript sequence homologies, and cross-genome sequence homologies between S. mansoni and Schistosoma japonicum to define a comprehensive list of protein-coding genes.},
	keywords = {Annotation, Gene finding, Genome, Schistosoma mansoni},
	isbn = {0014-4894},
	doi = {16/j.exppara.2007.06.005},
	url = {http://www.sciencedirect.com/science/article/pii/S0014489407001683},
	author = {Haas,Brian J. and Berriman,Matthew and Hirai,Hirohisa and Cerqueira,Gustavo G. and LoVerde,Philip T. and El-Sayed, Najib M.}
}
@article {14069,
	title = {Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: Sixteen new members and a novel subfamily},
	journal = {Gene},
	volume = {366},
	year = {2006},
	month = {2006/02/01/},
	pages = {303 - 315},
	abstract = {Nuclear receptors (NRs) are important transcriptional modulators in metazoans. Sixteen new NRs were identified in the Platyhelminth trematode, Schistosoma mansoni. Three were found to possess novel tandem DNA-binding domains that identify a new subfamily of NR. Two NRs are homologues of the thyroid hormone receptor that previously were thought to be restricted to chordates. This study brings the total number of identified NR in S. mansoni to 21. Phylogenetic and comparative genomic analyses demonstrate that S. mansoni NRs share an evolutionary lineage with that of arthropods and vertebrates. Phylogenic analysis shows that more than half of the S. mansoni nuclear receptors evolved from a second gene duplication. As the second gene duplication of NRs was thought to be specific to vertebrates, our data challenge the current theory of NR evolution.},
	keywords = {Nuclear receptors, Schistosoma mansoni},
	isbn = {0378-1119},
	doi = {16/j.gene.2005.09.013},
	url = {http://www.sciencedirect.com/science/article/pii/S0378111905005871},
	author = {Wu,Wenjie and Niles,Edward G. and El-Sayed, Najib M. and Berriman,Matthew and LoVerde,Philip T.}
}
@article {14070,
	title = {Schistosoma mansoni genome project: an update},
	journal = {Parasitology International},
	volume = {53},
	year = {2004},
	month = {2004/06//},
	pages = {183 - 192},
	abstract = {A schistosome genome project was initiated by the World Health Organization in 1994 with the notion that the best prospects for identifying new targets for drugs, vaccines, and diagnostic development lie in schistosome gene discovery, development of chromosome maps, whole genome sequencing and genome analysis. Schistosoma mansoni has a haploid genome of 270 Mb contained on 8 pairs of chromosomes. It is estimated that the S. mansoni genome contains between 15~000 and 25~000 genes. There are approximately 16~689 ESTs obtained from diverse libraries representing different developmental stages of S. mansoni, deposited in the NCBI EST database. More than half of the deposited sequences correspond to genes of unknown function. Approximately 40-50\% of the sequences form unique clusters, suggesting that approximately 20-25\% of the total schistosome genes have been discovered. Efforts to develop low resolution chromosome maps are in progress. There is a genome sequencing program underway that will provide 3X sequence coverage of the S. mansoni genome that will result in approximately 95\% gene discovery. The genomics era has provided the resources to usher in the era of functional genomics that will involve microarrays to focus on specific metabolic pathways, proteomics to identify relevant proteins and protein-protein interactions to understand critical parasite pathways. Functional genomics is expected to accelerate the development of control and treatment strategies for schistosomiasis.},
	keywords = {Chromosome mapping, Gene discovery, Genomics, Schistosoma mansoni},
	isbn = {1383-5769},
	doi = {16/j.parint.2004.01.009},
	url = {http://www.sciencedirect.com/science/article/pii/S1383576904000108},
	author = {LoVerde,Philip T. and Hirai,Hirohisa and Merrick,Joseph M and Lee,Norman H and El-Sayed, Najib M.}
}
