@article {19655,
	title = {Differential positioning of adherens junctions is associated with initiation of epithelial folding},
	journal = {Nature},
	volume = {484},
	year = {2012},
	month = {2012/04/19/},
	pages = {390 - 393},
	abstract = {During tissue morphogenesis, simple epithelial sheets undergo folding to form complex structures. The prevailing model underlying epithelial folding involves cell shape changes driven by myosin-dependent apical constriction. Here we describe an alternative mechanism that requires differential positioning of adherens junctions controlled by modulation of epithelial apical{\textendash}basal polarity. Using live embryo imaging, we show that before the initiation of dorsal transverse folds during Drosophila gastrulation, adherens junctions shift basally in the initiating cells, but maintain their original subapical positioning in the neighbouring cells. Junctional positioning in the dorsal epithelium depends on the polarity proteins Bazooka and Par-1. In particular, the basal shift that occurs in the initiating cells is associated with a progressive decrease in Par-1 levels. We show that uniform reduction of the activity of Bazooka or Par-1 results in uniform apical or lateral positioning of junctions and in each case dorsal fold initiation is abolished. In addition, an increase in the Bazooka/Par-1 ratio causes formation of ectopic dorsal folds. The basal shift of junctions not only alters the apical shape of the initiating cells, but also forces the lateral membrane of the adjacent cells to bend towards the initiating cells, thereby facilitating tissue deformation. Our data thus establish a direct link between modification of epithelial polarity and initiation of epithelial folding.},
	keywords = {cell biology, developmental biology},
	isbn = {0028-0836},
	url = {http://www.nature.com/nature/journal/v484/n7394/abs/nature10938.html},
	author = {Wang, Yu-Chiun and Zia Khan and Kaschube, Matthias and Wieschaus, Eric F.}
}
@article {12888,
	title = {Microbial oceanography in a sea of opportunity},
	journal = {Nature},
	volume = {459},
	year = {2009},
	month = {2009/05/13/},
	pages = {180 - 184},
	abstract = {Plankton use solar energy to drive the nutrient cycles that make the planet habitable for larger organisms. We can now explore the diversity and functions of plankton using genomics, revealing the gene repertoires associated with survival in the oceans. Such studies will help us to appreciate the sensitivity of ocean systems and of the ocean{\textquoteright}s response to climate change, improving the predictive power of climate models.},
	keywords = {Astronomy, astrophysics, Biochemistry, Bioinformatics, Biology, biotechnology, cancer, cell cycle, cell signalling, climate change, Computational Biology, development, developmental biology, DNA, drug discovery, earth science, ecology, environmental science, Evolution, evolutionary biology, functional genomics, Genetics, Genomics, geophysics, immunology, interdisciplinary science, life, marine biology, materials science, medical research, medicine, metabolomics, molecular biology, molecular interactions, nanotechnology, Nature, neurobiology, neuroscience, palaeobiology, pharmacology, Physics, proteomics, quantum physics, RNA, Science, science news, science policy, signal transduction, structural biology, systems biology, transcriptomics},
	isbn = {0028-0836},
	doi = {10.1038/nature08056},
	url = {http://www.nature.com/nature/journal/v459/n7244/abs/nature08056.html},
	author = {Bowler,Chris and Karl,David M. and Rita R Colwell}
}
@article {18717,
	title = {Structural Biology: Analysis of {\textquoteright}downhill{\textquoteright} protein folding; Analysis of protein-folding cooperativity (Reply)},
	journal = {Nature},
	volume = {445},
	year = {2007},
	month = {2007/02/15/},
	pages = {E17-E18 - E17-E18},
	abstract = {Ferguson et al. and Zhou and Bai criticize the quality of our nuclear magnetic resonance (NMR) data and atom-by-atom analysis of global {\textquoteright}downhill{\textquoteright} folding, also claiming that the data are compatible with two-state folding.},
	keywords = {Astronomy, astrophysics, Biochemistry, Bioinformatics, Biology, biotechnology, cancer, cell cycle, cell signalling., climate change, Computational Biology, development, developmental biology, DNA, drug discovery, earth science, ecology, environmental science, Evolution, evolutionary biology, functional genomics, Genetics, Genomics, geophysics, immunology, interdisciplinary science, life, marine biology, materials science, medical research, medicine, metabolomics, molecular biology, molecular interactions, nanotechnology, Nature, neurobiology, neuroscience, palaeobiology, pharmacology, Physics, proteomics, quantum physics, RNA, Science, science news, science policy, signal transduction, structural biology, systems biology, transcriptomics},
	isbn = {0028-0836},
	doi = {10.1038/nature05645},
	url = {http://www.nature.com/nature/journal/v445/n7129/full/nature05645.html?lang=en},
	author = {Sadqi,Mourad and Fushman, David and Mu{\~n}oz,Victor}
}
