@article {17487,
	title = {Visual Exploration across Biomedical Databases},
	journal = {IEEE/ACM Transactions on Computational Biology and Bioinformatics},
	volume = {8},
	year = {2011},
	month = {2011/04//March},
	pages = {536 - 550},
	abstract = {Though biomedical research often draws on knowledge from a wide variety of fields, few visualization methods for biomedical data incorporate meaningful cross-database exploration. A new approach is offered for visualizing and exploring a query-based subset of multiple heterogeneous biomedical databases. Databases are modeled as an entity-relation graph containing nodes (database records) and links (relationships between records). Users specify a keyword search string to retrieve an initial set of nodes, and then explore intra- and interdatabase links. Results are visualized with user-defined semantic substrates to take advantage of the rich set of attributes usually present in biomedical data. Comments from domain experts indicate that this visualization method is potentially advantageous for biomedical knowledge exploration.},
	keywords = {Bioinformatics, Biomedical computing, biomedical databases, cross-database exploration, Data exploration and discovery, Data visualization, database management systems, Databases, Factual, DNA, graph theory, Information Storage and Retrieval, information visualization., Keyword search, medical computing, natural language processing, Proteins, semantic networks, semantics, sequences, text mining, User-Computer Interface, user-defined semantics, visual databases},
	isbn = {1545-5963},
	doi = {10.1109/TCBB.2010.1},
	author = {Lieberman,M.D. and Taheri, S. and Guo,Huimin and Mirrashed,F. and Yahav,I. and Aris,A. and Shneiderman, Ben}
}
@article {12814,
	title = {High-confidence medical device software and systems},
	journal = {Computer},
	volume = {39},
	year = {2006},
	month = {2006/04//},
	pages = {33 - 38},
	abstract = {Given the shortage of caregivers and the increase in an aging US population, the future of US healthcare quality does not look promising and definitely is unlikely to be cheaper. Advances in health information systems and healthcare technology offer a tremendous opportunity for improving the quality of care while reducing costs. The development and production of medical device software and systems is a crucial issue, both for the US economy and for ensuring safe advances in healthcare delivery. As devices become increasingly smaller in physical terms but larger in software terms, the design, testing, and eventual Food and Drug Administration (FDA) device approval is becoming much more expensive for medical device manufacturers both in terms of time and cost. Furthermore, the number of devices that have recently been recalled due to software and hardware problems is increasing at an alarming rate. As medical devices are becoming increasingly networked, ensuring even the same level of health safety seems a challenge.},
	keywords = {Aging, biomedical equipment, Clinical software engineering, Costs, FDA device, Food and Drug Administration device, health and safety, health care, health information system, health safety, healthcare delivery, Healthcare technology, Information systems, medical computing, medical device manufacturing, medical device software development, medical device systems development, medical information systems, Medical services, Medical software, Medical tests, networked medical devices, Production systems, Software design, Software safety, Software systems, Software testing, US healthcare quality},
	isbn = {0018-9162},
	doi = {10.1109/MC.2006.127},
	author = {Lee,I. and Pappas,G. J and Cleaveland, Rance and Hatcliff,J. and Krogh,B. H and Lee,P. and Rubin,H. and Sha,L.}
}
@article {16949,
	title = {A telescope for high-dimensional data},
	journal = {Computing in Science \& Engineering},
	volume = {8},
	year = {2006},
	month = {2006/04//March},
	pages = {48 - 53},
	abstract = {Muscular dystrophy is a degenerative disease that destroys muscles and ultimately kills its victims. Researchers worldwide are racing to find a cure by trying to uncover the genetic processes that cause it. Given that a key process is muscle development, researchers at a consortium of 10 institutions are studying 1,000 men and women, ages 18 to 40 years, to see how their muscles enlarge with exercise. The 150 variables collected for each participant will make this data analysis task challenging for users of traditional statistical software tools. However, a new approach to visual data analysis is helping these researchers speed up their work. At the University of Maryland{\textquoteright}s Human-Computer Interaction Library, we developed an interactive approach to let researchers explore high-dimensional data in an orderly manner, focusing on specific features one at a time. The rank-by-feature framework lets them adjust controls to specify what they{\textquoteright}re looking for, and then, with only a glance, they can spot strong relationships among variables, find tight data clusters, or identify unexpected gaps. Sometimes surprising outliers invite further study as to whether they represent errors or an unusual outcome. Similar data analysis problems come up in meteorology, finance, chemistry, and other sciences in which complex relationships among many variables govern outcomes. The rank-by-feature framework could be helpful to many researchers, engineers, and managers because they can then steer their analyses toward the action},
	keywords = {Chemistry, Data analysis, data mining, data visualisation, degenerative disease, Degenerative diseases, diseases, Finance, genetic process, Genetics, high-dimensional data, interactive data analysis, medical computing, Meteorology, muscle, muscle development, Muscles, muscular dystrophy, Rank-by-feature framework, software, software libraries, software tools, Telescopes, visual data, visual data analysis},
	isbn = {1521-9615},
	doi = {10.1109/MCSE.2006.21},
	author = {Shneiderman, Ben}
}
