@article {14072,
	title = {Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non-lethal cold shock},
	journal = {Environmental Microbiology},
	volume = {7},
	year = {2005},
	month = {2005/06/01/},
	pages = {789 - 797},
	abstract = {Temperature shock of the hyperthermophilic methanarchaeon Methanococcus jannaschii from its optimal growth temperature of 85{\textdegree}C to 65{\textdegree}C and 95{\textdegree}C resulted in different transcriptional responses characteristic of both the direction of shock (heat or cold shock) and whether the shock was lethal. Specific outcomes of lethal heat shock to 95{\textdegree}C included upregulation of genes encoding chaperones, and downregulation of genes encoding subunits of the H+ transporting ATP synthase. A gene encoding an α subunit of a putative prefoldin was also upregulated, which may comprise a novel element in the protein processing pathway in M. jannaschii. Very different responses were observed upon cold shock to 65{\textdegree}C. These included upregulation of a gene encoding an RNA helicase and other genes involved in transcription and translation, and upregulation of genes coding for proteases and transport proteins. Also upregulated was a gene that codes for an 18~kDa FKBP-type PPIase, which may facilitate protein folding at low temperatures. Transcriptional profiling also revealed several hypothetical proteins that respond to temperature stress conditions.},
	isbn = {1462-2920},
	doi = {10.1111/j.1462-2920.2005.00751.x},
	url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1462-2920.2005.00751.x/abstract},
	author = {Boonyaratanakornkit,Boonchai B and Simpson,Anjana J. and Whitehead,Timothy A and Fraser,Claire M. and El-Sayed, Najib M. and Clark,Douglas S}
}
