The genome sequence of Drosophila melanogaster

TitleThe genome sequence of Drosophila melanogaster
Publication TypeJournal Articles
Year of Publication2000
AuthorsAdams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, others
JournalScience
Volume287
Issue5461
Pagination2185 - 2185
Date Published2000///
ISBN Number0036-8075, 1095-9203
Abstract

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of theDrosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegansgenome, but with comparable functional diversity.

URLhttp://www.sciencemag.org/content/287/5461/2185
DOI10.1126/science.287.5461.2185