%0 Journal Article %J Science %D 2002 %T Comparative Genome Sequencing for Discovery of Novel Polymorphisms in Bacillus Anthracis %A Read,Timothy D. %A Salzberg,Steven L. %A Pop, Mihai %A Shumway,Martin %A Umayam,Lowell %A Jiang,Lingxia %A Holtzapple,Erik %A Busch,Joseph D %A Smith,Kimothy L %A Schupp,James M %A Solomon,Daniel %A Keim,Paul %A Fraser,Claire M. %X Comparison of the whole-genome sequence ofBacillus anthracis isolated from a victim of a recent bioterrorist anthrax attack with a reference reveals 60 new markers that include single nucleotide polymorphisms (SNPs), inserted or deleted sequences, and tandem repeats. Genome comparison detected four high-quality SNPs between the two sequenced B. anthracischromosomes and seven differences among different preparations of the reference genome. These markers have been tested on a collection of anthrax isolates and were found to divide these samples into distinct families. These results demonstrate that genome-based analysis of microbial pathogens will provide a powerful new tool for investigation of infectious disease outbreaks. %B Science %V 296 %P 2028 - 2033 %8 2002/06/14/ %@ 0036-8075, 1095-9203 %G eng %U http://www.sciencemag.org/content/296/5575/2028 %N 5575 %R 10.1126/science.1071837