TY - JOUR T1 - The Genome Sequence of Trypanosoma Cruzi, Etiologic Agent of Chagas Disease JF - ScienceScience Y1 - 2005 A1 - El‐Sayed, Najib M. A1 - Myler,Peter J. A1 - Bartholomeu,Daniella C. A1 - Nilsson,Daniel A1 - Aggarwal,Gautam A1 - Tran,Anh-Nhi A1 - Ghedin,Elodie A1 - Worthey,Elizabeth A. A1 - Delcher,Arthur L. A1 - Blandin,Gaëlle A1 - Westenberger,Scott J. A1 - Caler,Elisabet A1 - Cerqueira,Gustavo C. A1 - Branche,Carole A1 - Haas,Brian A1 - Anupama,Atashi A1 - Arner,Erik A1 - Åslund,Lena A1 - Attipoe,Philip A1 - Bontempi,Esteban A1 - Bringaud,Frédéric A1 - Burton,Peter A1 - Cadag,Eithon A1 - Campbell,David A. A1 - Carrington,Mark A1 - Crabtree,Jonathan A1 - Darban,Hamid A1 - da Silveira,Jose Franco A1 - de Jong,Pieter A1 - Edwards,Kimberly A1 - Englund,Paul T. A1 - Fazelina,Gholam A1 - Feldblyum,Tamara A1 - Ferella,Marcela A1 - Frasch,Alberto Carlos A1 - Gull,Keith A1 - Horn,David A1 - Hou,Lihua A1 - Huang,Yiting A1 - Kindlund,Ellen A1 - Klingbeil,Michele A1 - Kluge,Sindy A1 - Koo,Hean A1 - Lacerda,Daniela A1 - Levin,Mariano J. A1 - Lorenzi,Hernan A1 - Louie,Tin A1 - Machado,Carlos Renato A1 - McCulloch,Richard A1 - McKenna,Alan A1 - Mizuno,Yumi A1 - Mottram,Jeremy C. A1 - Nelson,Siri A1 - Ochaya,Stephen A1 - Osoegawa,Kazutoyo A1 - Pai,Grace A1 - Parsons,Marilyn A1 - Pentony,Martin A1 - Pettersson,Ulf A1 - Pop, Mihai A1 - Ramirez,Jose Luis A1 - Rinta,Joel A1 - Robertson,Laura A1 - Salzberg,Steven L. A1 - Sanchez,Daniel O. A1 - Seyler,Amber A1 - Sharma,Reuben A1 - Shetty,Jyoti A1 - Simpson,Anjana J. A1 - Sisk,Ellen A1 - Tammi,Martti T. A1 - Tarleton,Rick A1 - Teixeira,Santuza A1 - Van Aken,Susan A1 - Vogt,Christy A1 - Ward,Pauline N. A1 - Wickstead,Bill A1 - Wortman,Jennifer A1 - White,Owen A1 - Fraser,Claire M. A1 - Stuart,Kenneth D. A1 - Andersson,Björn AB - Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. VL - 309 SN - 0036-8075, 1095-9203 UR - http://www.sciencemag.org/content/309/5733/409 CP - 5733 M3 - 10.1126/science.1112631 ER -