TY - JOUR T1 - 2009 Swine-Origin Influenza A (H1N1) Resembles Previous Influenza Isolates JF - PLoS ONEPLoS ONE Y1 - 2009 A1 - Kingsford, Carl A1 - Nagarajan,Niranjan A1 - Salzberg,Steven L. AB - In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1). Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans. VL - 4 UR - http://dx.doi.org/10.1371/journal.pone.0006402 CP - 7 M3 - 10.1371/journal.pone.0006402 ER -