@article {17259,
	title = {Interactively exploring hierarchical clustering results [gene identification]},
	journal = {Computer},
	volume = {35},
	year = {2002},
	month = {2002/07//},
	pages = {80 - 86},
	abstract = {To date, work in microarrays, sequenced genomes and bioinformatics has focused largely on algorithmic methods for processing and manipulating vast biological data sets. Future improvements will likely provide users with guidance in selecting the most appropriate algorithms and metrics for identifying meaningful clusters-interesting patterns in large data sets, such as groups of genes with similar profiles. Hierarchical clustering has been shown to be effective in microarray data analysis for identifying genes with similar profiles and thus possibly with similar functions. Users also need an efficient visualization tool, however, to facilitate pattern extraction from microarray data sets. The Hierarchical Clustering Explorer integrates four interactive features to provide information visualization techniques that allow users to control the processes and interact with the results. Thus, hybrid approaches that combine powerful algorithms with interactive visualization tools will join the strengths of fast processors with the detailed understanding of domain experts},
	keywords = {algorithmic methods, arrays, Bioinformatics, biological data sets, biology computing, Data analysis, data mining, data visualisation, Data visualization, DNA, Fluorescence, gene functions, gene identification, gene profiles, Genetics, Genomics, Hierarchical Clustering Explorer, hierarchical systems, interactive exploration, interactive information visualization tool, interactive systems, Large screen displays, meaningful cluster identification, metrics, microarray data analysis, pattern clustering, pattern extraction, Process control, Sensor arrays, sequenced genomes, Tiles},
	isbn = {0018-9162},
	doi = {10.1109/MC.2002.1016905},
	author = {Seo,Jinwook and Shneiderman, Ben}
}
@article {18703,
	title = {Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity},
	journal = {Journal of Molecular Biology},
	volume = {255},
	year = {1996},
	month = {1996/01/12/},
	pages = {14 - 21},
	abstract = {It has recently been suggested that pleckstrin homology (PH) domains bind specifically to phospholipids, with phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) being most strongly bound. This observation suggests that PH domains may be responsible for membrane association of proteins in which they occur. Further, this membrane association may be regulated by enzymes that modify lipid head groups to which PH domains may bind. We have studied the binding of phospholipids to the PH domain of human dynamin, a 100 kDa GTPase that is involved in the initial stages of endocytosis. We describe a rapid method for screening PH domain/ligand interactions that gives precise binding constants. We confirm that PtdIns(4,5)P2can bind to dynamin PH domain, although not in an aggregated state. Using NMR spectroscopy, we have mapped a specific site on the surface of dynamin PH domain of which binding of gIns(1,4,5)P3(the head-group skeleton of PtdIns(4,5)P2) occurs. The relative affinity of acidic phospholipids for dynamin PH domain correlates with their ability to activate the GTPase of dynamin. We propose, therefore, that the interaction of these phospholipids with dynamin is likely to occurviathe PH domain. Given the fact that PH domains are often found in pro- teins associated with GTPase activity, or in guanine nucleotide exchange factors, we suggest that one role of PH domains may be to couple phosphatidylinositol signalling to GTP hydrolysis.},
	keywords = {Fluorescence, ligand binding, NMR, PH domain, phospholipid},
	isbn = {0022-2836},
	doi = {10.1006/jmbi.1996.0002},
	url = {http://www.sciencedirect.com/science/article/pii/S0022283696900029},
	author = {Zheng,Jie and Cahill,Sean M. and Lemmon,Mark A. and Fushman, David and Schlessinger,Joseph and Cowburn,David}
}
