@article {18977,
	title = {Genetic depletion reveals an essential role for an SR protein splicing factor in vertebrate cells},
	journal = {BioEssays},
	volume = {19},
	year = {1997},
	month = {1997///},
	pages = {189 - 192},
	abstract = {SR proteins are essential for the splicing of messenger RNA precursors in vitro, where they also alter splice site selection in a concentration-dependent manner. Although experiments involving overexpression or dominant mutations have confirmed that these proteins can influence RNA processing decisions in vivo, similar results with loss-of-function mutations have been lacking. Now, a system for genetic depletion of the chicken B cell line DT40 has revealed that the SR protein ASF/SF2 (alternative splicing factor/splicing factor 2) is essential for viability in these cells(1). This study opens the way for a complete functional dissection of this protein, and other SR proteins, in vivo.},
	isbn = {1521-1878},
	doi = {10.1002/bies.950190302},
	url = {http://onlinelibrary.wiley.com/doi/10.1002/bies.950190302/abstract},
	author = {Mount, Stephen M.}
}
